The application of conductive hydrogels for self-powered wearable devices: medical field

Authors

  • Chenxiao Geng

DOI:

https://doi.org/10.61173/by54fx47

Keywords:

Conductive hydrogels, Self-powered wearables, Biomedical engineering

Abstract

Wearable devices are playing an increasingly important role in various fields, particularly in healthcare. These devices not only detect vital signs but also quantify health indicators and thus play a crucial role in disease prevention. The demand for flexible wearable devices continues to rise. In this context, conductive hydrogels (CHs) have emerged as a novel flexible material that has garnered significant attention from researchers due to its excellent flexibility and biocompatibility. This article will focus on the applications and recent advancements of conductive hydrogels in the medical field, particularly in self-powered devices. Based on their functions, the applications can be categorized into two main areas: medical detection and treatment. In the realm of medical detection, conductive hydrogels can monitor physiological signals in real-time, such as electrocardiograms (ECG), electromyograms (EMG), and skin temperature. Researchers have successfully combined conductive hydrogels with flexible electrodes to achieve highly sensitive signal acquisition. This technological advancement enables long-term monitoring, greatly enhancing patient comfort and convenience. In terms of treatment, conductive hydrogels are applied in electrical stimulation therapies and drug delivery systems. They not only effectively conduct electricity but also can interact with drugs to achieve precise therapeutic effects. Despite their promise, challenges remain, including long-term stability, material integration, and scaling up manufacturing processes. Overall, the future of conductive hydrogels in wearable devices is promising, poised to advance personalized medicine and smart health management.

References

[1] Ates, H. C., P. Q. Nguyen, L. Gonzalez-Macia, E. Morales- Narváz, F. Guder, J. J. Collins and C. Dincer (2022). „End-toend design of wearable sensors.“ Nature Reviews Materials 7(11): 887-907.

[2] Buwalda, S. J., K. W. M. Boere, P. J. Dijkstra, J. Feijen, T. Vermonden and W. E. Hennink (2014). „Hydrogels in a historical perspective: From simple networks to smart materials.“ Journal of Controlled Release 190: 254-273. Dean&Francis ISSN 2959-6157

[3] Chen, A., J. Zhang, J. Zhu, Z. Yan, Q. Wu, S. Han, J. Huang and L. Guan (2023). „Self-adhesive electronic skin for ultrasensitive healthcare monitoring.“ Journal of Materials Chemistry A 11(10): 4977-4986.

[4] Chen, L., Z. Wang, Z. Zhan, M. Xie, G. Duan, P. Cheng, Y. Chen and H. Duan (2021). „3D printed super-anti-freezing selfadhesive human-machine interface.“ Materials Today Physics 19.

[5] Chen, R. S., M. Y. Gao, D. W. Chu, W. L. Cheng and Y. R. Lu (2024). „Self-powered hydrogel wearable bioelectronics.“ Nano Energy 128.

[6] Chen, Z., Y. J. Chen, M. S. Hedenqvist, C. Chen, C. Cai, H. Li, H. Z. Liu and J. Fu (2021). „Multifunctional conductive hydrogels and their applications as smart wearable devices.“ Journal of Materials Chemistry B 9(11): 2561-2583.

[7] Du, S., N. Zhou, Y. Gao, G. Xie, H. Du, H. Jiang, L. Zhang, J. Tao and J. Zhu (2020). „Bioinspired hybrid patches with selfadhesive hydrogel and piezoelectric nanogenerator for promoting skin wound healing.“ Nano Research 13(9): 2525-2533.

[8] Garcia-Torres, J., S. Colombi, I. Mahamed, D. Sylla, M. Arnau, J. Sans, M. P. Ginebra and C. Aleman (2023). „Nanocomposite Hydrogels with Temperature Response for Capacitive Energy Storage.“ Acs Applied Energy Materials 6(8): 4487-4495.

[9] Garland, N. T., J. W. Song, T. Ma, Y. J. Kim, A. Vazquez- Guardado, A. B. Hashkavayi, S. K. Ganeshan, N. Sharma, H. Ryu, M.-K. Lee, B. Sumpio, M. A. Jakus, V. Forsberg, R. Kaveti, S. K. Sia, A. Veves, J. A. Rogers, G. A. Ameer and A. J. Bandodkar (2023). „A Miniaturized, Battery-Free, Wireless Wound Monitor That Predicts Wound Closure Rate Early.“ Advanced Healthcare Materials 12(28).

[10] Guo, H., M. Bai, Y. Zhu, X. Liu, S. Tian, Y. Long, Y. Ma, C. Wen, Q. Li, J. Yang and L. Zhang (2021). „Pro-Healing Zwitterionic Skin Sensor Enables Multi-Indicator Distinction and Continuous Real-Time Monitoring.“ Advanced Functional Materials 31(50).

[11] Huang, J. R., S. J. Peng, J. F. Gu, G. Q. Chen, J. H. Gao, J. Zhang, L. X. Hou, X. X. Yang, X. C. Jiang and L. H. Guan (2020). „Self-powered integrated system of a strain sensor and flexible all-solid-state supercapacitor by using a high performance ionic organohydrogel.“ Materials Horizons 7(8): 2085-2096.

[12] Huang, X. Y., L. Wang, H. C. Wang, B. Z. Zhang, X. B. Wang, R. Y. Z. Stening, X. Sheng and L. Yin (2020). „Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics.“ Small 16(15).

[13] Hui, Y., Y. Yao, Q. L. Qian, J. H. Luo, H. H. Chen, Z. Qiao, Y. T. Yu, L. Tao and N. J. Zhou (2022). „Three-dimensional printing of soft hydrogel electronics.“ Nature Electronics.

[14] Jeong, S.-H., Y. Lee, M.-G. Lee, W. J. Song, J.-U. Park and J.-Y. Sun (2021). „Accelerated wound healing with an ionic patch assisted by a triboelectric nanogenerator.“ Nano Energy 79.

[15] Jiang, Y., A. A. Trotsyuk, S. Niu, D. Henn, K. Chen, C.-C. Shih, M. R. Larson, A. M. Mermin-Bunnell, S. Mittal, J.-C. Lai, A. Saberi, E. Beard, S. Jing, D. Zhong, S. R. Steele, K. Sun, T. Jain, E. Zhao, C. R. Neimeth, W. G. Viana, J. Tang, D. Sivaraj, J. Padmanabhan, M. Rodrigues, D. P. Perrault, A. Chattopadhyay, Z. N. Maan, M. C. Leeolou, C. A. Bonham, S. H. Kwon, H. C. Kussie, K. S. Fischer, G. Gurusankar, K. Liang, K. Zhang, R. Nag, M. P. Snyder, M. Januszyk, G. C. Gurtner and Z. Bao (2023). „Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing.“ Nature Biotechnology 41(5): 652-+.

[16] Jung, S., H. Yong, S. Park, D. Kim, S. Ryu, Y. H. Kim, B. Choi, W. Choi, J. S. Lee, J. Yoo, J. Hong and S. Lee (2022). „Body-Mediated Bioelectronics for Zero-Powered Ion Release and Electrical Stimulation.“ Acs Energy Letters 7(11): 3997- 4004.

[17] Keum, D. H., S.-K. Kim, J. Koo, G.-H. Lee, C. Jeon, J. W. Mok, B. H. Mun, K. J. Lee, E. Kamrani, C.-K. Joo, S. Shin, J.- Y. Sim, D. Myung, S. H. Yun, Z. Bao and S. K. Hahn (2020). „Wireless smart contact lens for diabetic diagnosis and therapy.“ Science Advances 6(17).

[18] Larson, C., B. Peele, S. Li, S. Robinson, M. Totaro, L. Beccai, B. Mazzolai and R. Shepherd (2016). „Highly stretchable electroluminescent skin for optical signaling and tactile sensing.“ Science 351(6277): 1071-1074.

[19] Li, W. W., J. Liu, J. N. Wei, Z. Y. Yang, C. L. Ren and B. X. Li (2023). „Recent Progress of Conductive Hydrogel Fibers for Flexible Electronics: Fabrications, Applications, and Perspectives.“ Advanced Functional Materials 33(17).

[20] Liang, Y., Q. Ding, H. Wang, Z. Wu, J. Li, Z. Li, K. Tao, X. Gui and J. Wu (2022). „Humidity Sensing of Stretchable and Transparent Hydrogel Films for Wireless Respiration Monitoring.“ Nano-Micro Letters 14(1).

[21] Lim, H. R., H. S. Kim, R. Qazi, Y. T. Kwon, J. W. Jeong and W. H. Yeo (2020). „Advanced Soft Materials, Sensor Integrations, and Applications of Wearable Flexible Hybrid Electronics in Healthcare, Energy, and Environment.“ Advanced Materials 32(15).

[22] Ling, Y. Z., T. C. An, L. W. Yap, B. W. Zhu, S. Gong and W. L. Cheng (2020). „Disruptive, Soft, Wearable Sensors.“ Advanced Materials 32(18).

[23] Paosangthong, W., R. Torah and S. Beeby (2019). „Recent progress on textile-based triboelectric nanogenerators.“ Nano Energy 55: 401-423.

[24] Penzel, T., C. Schobel and I. Fietze (2018). „New technology to assess sleep apnea: wearables, smartphones, and accessories.“ F1000Research 7: 413-413.

[25] Qu, J., X. Zhao, Y. Liang, T. Zhang, P. X. Ma and B. Guo (2018). „Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.“ Biomaterials 183: 185-199.

[26] Shen, G. C., K. P. Gao, N. Zhao, Z. R. Yi, C. P. Jiang, B. Dean&Francis Chenxiao Geng Yang and J. Q. Liu (2021). „A novel flexible hydrogel electrode with a strong moisturizing ability for long-term EEG recording.“ Journal of Neural Engineering 18(6).

[27] Sheng, X. J., Z. Qin, H. P. Xu, X. K. Shu, G. Y. Gu and X. Y. Zhu (2021). „Soft ionic-hydrogel electrodes for electroencephalography signal recording.“ Science China- Technological Sciences 64(2): 273-282.

[28] Shi, Z., Y. Lu, S. Shen, Y. Xu, C. Shu, Y. Wu, J. Lv, X. Li, Z. Yan, Z. An, C. Dai, L. Su, F. Zhang and Q. Liu (2022). „Wearable battery-free theranostic dental patch for wireless intraoral sensing and drug delivery.“ Npj Flexible Electronics 6(1).

[29] Tang, W., L. Yin, J. R. Sempionatto, J.-M. Moon, H. Teymourian and J. Wang (2021). „Touch-Based Stressless Cortisol Sensing.“ Advanced Materials 33(18).

[30] Wang, C., E. Shirzaei Sani and W. Gao (2022). „Wearable Bioelectronics for Chronic Wound Management.“ Advanced Functional Materials 32(17).

[31] Xu, H., W. Zheng, Y. Zhang, D. Zhao, L. Wang, Y. Zhao, W. Wang, Y. Yuan, J. Zhang, Z. Huo, Y. Wang, N. Zhao, Y. Qin, K. Liu, R. Xi, G. Chen, H. Zhang, C. Tang, J. Yan, Q. Ge, H. Cheng, Y. Lu and L. Gao (2023). „A fully integrated, standalone stretchable device platform with in-sensor adaptive machine learning for rehabilitation.“ Nature communications 14(1): 7769- 7769.

[32] Yin, L., M. Cao, K. N. Kim, M. Lin, J.-M. Moon, J. R. Sempionatto, J. Yu, R. Liu, C. Wicker, A. Trifonov, F. Zhang, H. Hu, J. R. Moreto, J. Go, S. Xu and J. Wang (2022). „A stretchable epidermal sweat sensing platform with an integrated printed battery and electrochromic display.“ Nature Electronics 5(10): 694-705.

[33] Yuk, H., B. Y. Lu and X. H. Zhao (2019). „Hydrogel bioelectronics.“ Chemical Society Reviews 48(6): 1642-1667.

[34] Zhang, Y. C., Y. R. Tan, J. Z. Lao, H. J. Gao and J. Yu (2023). „Hydrogels for Flexible Electronics.“ Acs Nano 17(11): 9681- 9693.

[35] Zhang, Y. S. and A. Khademhosseini (2017). „Advances in engineering hydrogels.“ Science 356(6337).

[36] Zou, Y. J., V. Raveendran and J. Chen (2020). „Wearable triboelectric nanogenerators for biomechanical energy harvesting.“ Nano Energy 77.

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Published

2024-12-31

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Vol. 2 No. 6 (2024): Volume 2, Issue 6

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Articles

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