Evaluation and Treatment of Major Depressive Disorder Based on EEG Technology

Authors

  • Lei Xu

DOI:

https://doi.org/10.61173/h520s049

Keywords:

EEG, MDD, FAA, biomarkers, DBS

Abstract

Major depressive disorders (MDD) is a common mental disease that affects patients’ life quality and functioning and traditional diagnostic methods have errors so that new technological tools are urgently needed to improve the accuracy of diagnosis. The aim of the study is to investigate the application of electroencephalography (EEG) technology and to analyze the potential in the evaluation and treatment of patients with MDD. EEG technology can effectively identify specific frequency bands to patients, combining with the analysis of frontal alpha asymmetry (FAA), which could provide a new way in diagnosis of MDD. Meanwhile, deep brain electrical stimulation (DBS) technology offers new opportunities for targeted treatment. Studies have shown that EEG technology can improve the diagnostic accuracy of MDD. Additionally, the stimulation feedback mechanism of DBS technology in different brain regions provides new ideas for the treatment of Treatment-Resistant Depression (TRD).This study provides a scientific basis for the evaluation and treatment of MDD, and exhibits the future application of EEG and DBS technologies in the field of psychiatric disorders which may change the treatment paradigm for MDD patients.

References

[1] Liu Yuwei, Xia Shuyuan, Ren Qingfa, et al. Research progress in magnetic resonance imaging of amygdala in patients with major depression. Magnetic Resonance Imaging, 2017, 15(4): 177-181.

[2] Cui Lulu, Zhang Jie, Wang Li, et al. Major depressive disorder: hypothesis, mechanism, prevention and treatment. Signal Transduction and Targeted Therapy, 2024, 9(1): 30.

[3] Fava M, Kendler KS. Major depressive disorder. Neuron, 2000, 28(2): 335-341.

[4] Wang Shengsheng, Tan Zhonglin, Wu Yue, et al. Research progress of brain-computer interface in diagnosis and treatment of depression. Chinese Journal of Neuropsychiatric Disorders, 2019, 49(4): 251-256.

[5] Liu Zhaoxia, Zhang Wei, Li Hong, et al. Frontal alpha asymmetry in patients with first-episode unmedicated depression. Chinese Journal of Clinical Psychology, 2022, 30(3): 499-504.

[6] van der Vinne Nikita, Vollebregt Maarten A, van Putten Michel JAM, et al. Frontal alpha asymmetry as a diagnostic marker in depression: Fact or fiction? A meta-analysis. Neuroimage Clinical, 2017, 6: 79-87.

[7] Hu Bin, Wang Jian, Chen Min, et al. Emotion Regulating Attentional Control Abnormalities In Major Depressive Disorder: An Event-Related Potential Study. Scientific Reports, 2017, 7(1): 13530.

[8] Li Xiaowei, Zhang Hui, Liu Ming, et al. Attentional bias in MDD: ERP components analysis and classification using a dotprobe task. Computer Methods and Programs in Biomedicine, 2018, 164: 169-179.

[9] Goldschmied Jennifer R, Gehrman Philip, Perlis Michael L, et al. A preliminary investigation of the role of slow-wave activity in modulating waking EEG theta as a marker of sleep propensity in major depressive disorder. Journal of Affective Disorders, 2019, 257: 504-509.

[10] Gradwohl Gideon, Labounek Roman, Kratochvil Tomas, et al. Timing and cortical region matter: theta power differences between teenagers affected by Major Depression and healthy controls. Journal of Neural Transmission (Vienna), 2024, 131(9): 1105-1115.

[11] Liu Shuang, Yang Yu, Wang Jun, et al. Alterations in Patients With First-Episode Depression in the Eyes-Open and Eyes-Closed Conditions: A Resting-State EEG Study. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022, 30: 1019-1029.

[12] Sun M.X., Li Yan, Zhang Bin, et al. Effects of deep brain electrical stimulation of the thalamic floor nucleus on anxiety and depression in patients with Meige syndrome. Chinese Journal of Neuroimmunology and Neurology, 2024, 31(3): 198- 203.

[13] Scangos Katherine W, Makhoul George S, Sugrue Leo P, et al. State-dependent responses to intracranial brain stimulation in a patient with depression. Nature Medicine, 2021, 27(2): 229- 231.

[14] Rao VR, Sellers KK, Wallace DL, et al. Direct electrical stimulation of lateral orbitofrontal cortex acutely improves mood in individuals with symptoms of depression. Current Biology, 2018, 28(24): 3893-3902.

[15] Figee Martijn, Mayberg Helen S, Widge Alik S, et al. Deep Brain Stimulation for Depression. Neurotherapeutics, 2022, 19(4): 1229-1245.

[16] Lv X, Chen Yingying, Zhao Hong, et al. Progress of clinical efficacy and mechanism study of deep brain electrical stimulation for treatment-refractory depressive disorder. Chinese Journal of Neuropsychiatric Diseases, 2023, 49(11): 675-681.

[17] Bergfeld Isidoor O, Mantione Mariska, Hoogendoorn Maurice L, et al. Efficacy and quality of life after 6-9 years of deep brain stimulation for depression. Brain Stimulation, 2022, 15(4): 957-964.

Downloads

Published

2024-12-31

Issue

Vol. 2 No. 6 (2024): Volume 2, Issue 6

Section

Articles

License

Copyright (c) 2024 by the authors.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.