Transparent electrodes in neuroscience: Review

Authors

  • Zhanwen Zhang

DOI:

https://doi.org/10.61173/frabhk26

Keywords:

Transparent electrode, neuroscience, hybrid material

Abstract

Transparent electrodes have received increasing attention in neuroscience area such as neural interfaces, optogenetics and implantable neural sensors due to their unique ability to combine electrical conductivity with optical transparency, enabling simultaneous neural recording and stimulation without hindering optical techniques. This review concludes transparent electrodes into five categories including metal oxide-based, metal nanowire-based, conductive polymer-based, carbon-based as well as Hybrid materials and composite structure. Starting from the most widely used and earliest transparent material ITO, this review progressively covers the latest advances in hybrid materials and composite structures. For each classical material in different categories, their drawbacks, merits and current situations are introduced. Then the applications of transparent electrodes in the field of neuroscience are introduced, especially in relation to specific disease treatments. The application prospects of transparent electrodes in the field of neurology are broad, but they still face many technical challenges and problems. The future research should explore long-term implanted neural interfaces.

References

system for the treatment of epilepsy was verified in rats. Duan, X. (2018). Stretchable transparent electrode arrays for The system can record brain activity and perform electri- simultaneous electrical and optical interrogation of neural cal stimulation therapy. Through wireless transmission, circuits in vivo. Nano letters, 18(5), 2903-2911.

ECoG can transmit brain electrical activity signals to mo- [2] Cardin, J., Carlén, M., Meletis, K., & et al. (2010). Targeted bile phones and analyze epileptic seizures through cloud optogenetic stimulation and recording of neurons in vivo using processing. This experiment demonstrated the potential of cell-type-specific expression of Channelrhodopsin-2. Nature this system in the treatment of neurological diseases. This Protocols, 5(2), 247–254.

system provides a new method for epilepsy treatment [37]. [3] Cho, Y. U., Lim, S. L., Hong, J. H., & et al. (2022).

In 2018, the experiment used rats as a model to study the Transparent neural implantable devices: A comprehensive review relationship between neural activity and emotional regu- of challenges and progress. npj Flexible Electronics, 6(53).

lation by stimulating or inhibiting specific areas of their [4] Ellmer, K. (2012). Past achievements and future challenges brains. The researchers observed behavioral changes in in the development of optically transparent electrodes. Nature rats and the release of neurotransmitters in their brains to Photonics, 6(12), 809-817. understand the neural mechanisms and causes of depres- [5] Park, DW., Schendel, A., Mikael, S. et al. Graphene-based

sion [38]. In 2022, the experiment used optogenetics to carbon-layered electrode array technology for neural imaging

intervene in neural activity in specific brain regions and and optogenetic applications. Nat Commun 5, 5258 (2014). precisely regulate neuronal activity through light stimu- [6] Stadler A. Transparent Conducting Oxides—An Up-Tolation, as well as how to alleviate Alzheimer’s disease by Date Overview. Materials. 2012; 5(4):661-683. https://doi. combining non-pharmacological techniques [39]. org/10.3390/ma5040661. [7] Aydın, E. B., & Sezgintürk, M. K. (2017). Indium tin oxide (ITO): A promising material in biosensing technology. Trends in 4. Conclusion Analytical Chemistry, 97, 309-315.

The key role of transparent electrode materials in the field [8] Lang, U., Müller, E., Naujoks, N., & Dual, J. (2014). of neurology is reflected in the simultaneous transmission Transparent electrodes for organic optoelectronic devices: A of photoelectric signals. Because of the advantages of review. Journal of Photonics for Energy, 4(1), 040990.

transparent materials such as flexibility, biocompatibil- [9] Minami, T. (2005). Transparent conducting oxide ity, low invasiveness and high transparency, transparent semiconductors for transparent electrodes. Thin Solid Films, electrode materials are particularly suitable for neurol- 516(17), 5822-5828. ogy fields such as optogenetics, neural interfaces and [10] Chang, S., Chao, C., Lien, D., Yang, P., Wu, Y., Chen,

brain-computer interfaces. These advantages enable the W., & Hsu, C. (2023). Development of transparent conducting materials to play an important role in applications such as electrodes for optoelectronic application. Materials, 16(16), high-precision neural signal recording, stimulation, and 5537. Dean&Francis ISSN 2959-6157 [11] Li, X., Zhu, H., Wang, K., Cao, A., Wei, J., Li, C., Jia, Y., PEDOT: PSS. Advanced Materials, 31(10), 1806133.

Li, Z., & Wu, D. (2012). Graphene-on-silicon Schottky junction [27] López-Naranjo, E. J., González-Ortiz, L. J., Apátiga, L.

solar cells. Chinese Physics Letters, 29(3), 038103. M., Rivera-Muñoz, E. M., & Manzano-Ramírez, A. (2016). [12] Yu, Y., Ren, W., & Ren, B. (2008). Nanosize titanium Transparent electrodes: A review of the use of carbon‐based dioxide cause neuronal apoptosis: a potential linkage between nanomaterials. Journal of Nanomaterials, 2016(1), 4928365.

nanoparticle exposure and neural disorder. Neurological [28] Aloui, W., Ltaief, A., & Bouazizi, A. (2013). Transparent Research, 30(10), 1115–1120. and conductive multi walled carbon nanotubes flexible [13] Ge, R., Wu, X., Liu, K., Liu, X., Xu, K., & Ma, T. electrodes for optoelectronic applications. Superlattices and (2024). Advances in two-dimensional materials for flexible Microstructures, 64, 581-589.

optoelectronic devices. Chemical Society Reviews. [29] Lei, W., Lihui, L., & Shufen, C. (2021). Flexible Organic [14] Zhong, SJ., Chen, KY., Wang, SL. et al. Metal-based Light-Emitting Diodes Using Carbon-Based Transparent

nanowires in electrical biosensing. Rare Met. (2024). Electrodes. Progress in Chemistry, 33(5), 802. [15] Chen, Z., Ren, W., Gao, L., Liu, B., Pei, S., & Cheng, [30] Yun, H. D., Kwak, J., Kim, S. Y., Seo, H., Bang, I. C., Kim,

H.-M. (2016). Three-dimensional flexible and conductive S. Y., ... & Kwon, S. Y. (2016). High performance all-carbon interconnected graphene networks grown by chemical vapor composite transparent electrodes containing uniform carbon deposition. ACS Applied Materials & Interfaces, 8(42), 25962– nanotube networks. Journal of Alloys and Compounds, 675, 37- 25968. 45. [16] Li, N., & Zhang, G. (2016). Flexible and transparent [31] Abbas, S., Kumar, M., & Kim, J. (2018). All metal oxideconductive electrodes based on metal nanowire networks: A based transparent and flexible photodetector. Materials Sc review. Advanced Electronic Materials, 2(6), 1600121. [32] Sannicolo, T., Lagrange, M., Cabos, A., Celle, C., Simonato, [17] Zhu, R., Xu, J., Wang, Z., & Wang, J. (2016). Recent J. P., & Bellet, D. (2016). Metallic nanowire‐based transparent progress in flexible and stretchable piezoresistive devices for electrodes for next generation flexible devices: a review. Small, wearable electronics. Small, 12(36), 4848–4860. 12(44), 6052-6075. [18] Song, T. B., Rim, Y. S., Liu, F., Bob, B., Ye, S., Hsieh, Y. T., [33] Kim, Y. U., Park, S. H., Nhan, N. T., Hoang, M. H., Cho, & Yang, Y. (2015). Highly robust silver nanowire network for M. J., & Choi, D. H. (2021). Optimal design of PEDOT: PSS transparent electrode. ACS applied materials & interfaces, 7(44), polymer-based silver nanowire electrodes for realization of 24601-24607. flexible polymer solar cells. Macromolecular Research, 29, 75- [19] Zhang, R., & Engholm, M. (2018). Recent progress on the 81. fabrication and properties of silver nanowire-based transparent [34] Zhang, M., Fang, S., Zakhidov, A. A., Lee, S. B., Aliev,

electrodes. Nanomaterials, 8(8), 628.] A. E., Williams, C. D., ... & Baughman, R. H. (2005). Strong, [20] Scardaci, V. (2021). Copper nanowires for transparent transparent, multifunctional, carbon nanotube sheets. science, electrodes: Properties, challenges and applications. Applied 309(5738), 1215-1219. Sciences, 11(17), 8035. [35] Park, D. W., Ness, J. P., Brodnick, S. K., Esquibel, C., [21] Wang, Y., Cheng, J., Xing, Y., Shahid, M., Nishijima, H., & Novello, J., Atry, F., ... & Ma, Z. (2018). Electrical neural

Pan, W. (2017). Stretchable platinum network‐based transparent stimulation and simultaneous in vivo monitoring with transparent electrodes for highly sensitive wearable electronics. Small, graphene electrode arrays implanted in GCaMP6f mice. ACS 13(27), 1604291. nano, 12(1), 148-157. [22] Kim, J., Da Silva, W. J., bin Mohd Yusoff, A. R., & Jang, J. [36] Volkmann, J. (2004). Deep brain stimulation for (2016). Organic devices based on nickel nanowires transparent the treatment of Parkinson’s disease. Journal of clinical electrode. Scientific reports, 6(1), 19813. neurophysiology, 21(1), 6-17. [23] Shirakawa, H. (2001). The discovery of polyacetylene film– [37] Xie, K., Zhang, S., Dong, S., Li, S., Yu, C., Xu, K., ... &

the dawning of an era of conducting polymers. Current Applied Wu, Z. (2017). Portable wireless electrocorticography system Physics, 1(4-5), 281-286. with a flexible microelectrodes array for epilepsy treatment. [24] Wang, P. C., Liu, L. H., Mengistie, D. A., Li, K. H., Wen, B. Scientific reports, 7(1), 7808.

J., Liu, T. S., & Chu, C. W. (2013). Transparent electrodes based [38] Chen, S., Weitemier, A. Z., Zeng, X., He, L., Wang,

on conducting polymers for display applications. Displays, X., Tao, Y., ... & McHugh, T. J. (2018). Near-infrared deep 34(4), 301-314. brain stimulation via upconversion nanoparticle–mediated [25] Genies, E. M., Boyle, A., Lapkowski, M., & Tsintavis, C. optogenetics. Science, 359(6376), 679-684. (1990). Polyaniline: A historical survey. Synthetic metals, 36(2), [39] Ning, S., Jorfi, M., Patel, S. R., Kim, D. Y., & Tanzi, R. 139-182. E. (2022). Neurotechnological approaches to the diagnosis and [26] Kayser, L. V., & Lipomi, D. J. (2019). Stretchable treatment of Alzheimer’s disease. Frontiers in Neuroscience, 16, conductive polymers and composites based on PEDOT and 854992.

Downloads

Published

2024-12-31