Design of Optogenetic Microimplants for the Treatment of Neurodegenerative Disease
DOI:
https://doi.org/10.61173/vpxgz712Keywords:
Optogenetics, microimplants design, neurodegenerative diseaseAbstract
In the context of global aging, neurodegenerative diseases such as Alzheimer’s disease have become important issues in global public health and scientific research. This is due to their soaring incidence, serious impact on patients’ quality of life, and the huge burden they place on families and social economies. However, current treatments, such as drug therapy and deep brain stimulation, have obvious shortcomings. Moreover, there is a lack of precise neuromodulation tools to study the pathogenesis of these diseases In order to solve these problems, optogenetics has attracted attention in recent years, which uses light as a stimulus signal carrier and can realize the detection and control of neurodegenerative diseases at the level of neurons and neural circuits by implanting micro-implants such as μ leds. This review summarize the recent advances in microimplant technology in the fields of optogenetics and neuroscience, and summarize the development and application of optogenetic microimplants for the treatment of neurodegenerative diseases in detail.
References
[1] Khanam H, Ali A, Asif M, et al. Neurodegenerative diseases linked to misfolded proteins and their therapeutic approaches: A review. European Journal of Medicinal Chemistry, 2016, 124: 1121-1141.
[2] Michael Z, Mc Cormack Kasandra, van den Hurk Mark, et al. Brain Phys neuronal medium optimized for imaging and optogenetics in vitro. Nature Communications, 2020, 11: 5550.
[3] Spires-Jones TL, Attems J, Thal DR. Interactions of pathological proteins in neurodegenerative diseases. Acta Neuropathologica, 2017, 134(2): 187-205.
[4] Ackerman MJ, Clapham DE. Ion channels—basic science and clinical disease. New England Journal of Medicine, 1997, 336: 1575-1586.
[5] Boyden ES, Zhang Feng, Bamberg E, et al. Millisecondtimescale, genetically targeted optical control of neural activity. Nature Neuroscience, 2005, 8(9): 1263-1268.
[6] El-Shamayleh Y, Horwitz GD. Primate optogenetics: progress and prognosis. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116(52): 26195- 26203.
[7] Yue S. Research on implantable optoelectrodes based on μLED. Graduate University of Chinese Academy of Sciences (Changchun Institute of Optics, Fine Mechanics and Physics), 2015.
[8] Crick F. The impact of molecular biology on neuroscience. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1999, 354(1392): 2021-2025.
[9] Boyden ES, Zhang F, Bamberg E, et al. Millisecondtimescale, genetically targeted optical control of neural activity. Nature Neuroscience, 2005, 8(9): 1263-1268.
[10] Deisseroth K. Optogenetics: 10 years of microbial opsins in neuroscience. Nature Methods, 2012, 8(1): 26-29.
[11] Yoon HH, Park JH, Kim YH, et al. Optogenetic inactivation of the subthalamic nucleus improves forelimb akinesia in a rat model of Parkinson’s disease. Neurosurgery, 2014, 74(5): 533- 541.
[12] Lu Y, Zhong C, Wang L, et al. Optogenetic dissection of ictal propagation in the hippocampal–entorhinal cortex structures. Nature Communications, 2016, 7: 10962.
[13] Yang Licai, Li Baimin, Li Guanglin, et al. Review on braincomputer interface technology. Acta Electronica Sinica, 2005, (07): 1234-1241.
[14] (Title missing). Technology of deep brain stimulation: current status and future directions. (Additional information needed).
[15] Schiff ND, Giacino JT, Butson CR, et al. Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study. Nature Medicine, 2023, 29(12): 3162-3174.
[16] Musk E, Neuralink. An Integrated Brain-Machine Interface Platform With Thousands of Channels. Journal of Medical Internet Research, 2019, 21(10): e16194.
[17] Li Yan, Huang Wei, Huang Ping, et al. Antitumor drug delivery system. Advances in Chemistry, 2014, 26(08): 1395- 1408.
[18] Tian M, Ma Z, Yang GZ. Micro/nanosystems for controllable drug delivery to the brain. The Innovation, 2024, 5(1).
[19] Liu Y, Long LY, Zhang FJ, et al. Microneedle-mediated vascular endothelial growth factor delivery promotes angiogenesis and functional recovery after stroke. Journal of Controlled Release, 2021, 338: 610-622.
[20] Zhang H, Li Z, Gao C, et al. Dual-responsive biohybrid neutrobots for active target delivery. Science Robotics, 2021, 6(52): eaaz9519.
[21] Wu Hui, Cui-Hong Jin. The research progress of the pathogenesis of neurodegenerative diseases. Journal of Toxicology, 2018, 32(6): 484-488.
[22] Maisson DJN, Gemzik ZM, Griffin AL. Optogenetic suppression of the nucleus reuniens selectively impairs encoding during spatial working memory. Neurobiology of Learning and Memory, 2018, 155: 78-85.
[23] Polikov VS, Tresco PA, Reichert WM. Response of brain tissue to chronically implanted neural electrodes. Journal of Neuroscience Methods, 2005, 148(1): 1-18.
[24] Mickle AD, Won SM, Noh KN, et al. A wireless closedloop system for optogenetic peripheral neuromodulation. Nature, 2019, 565(7739): 361-365.
[25] Naughton JR, Connolly T, Varela JA, et al. Shielded Coaxial Optrode Arrays for Neurophysiology. Frontiers in Neuroscience, 2016, 10: 423.
[26] Zou L, Tian H, Guan S, et al. Self-assembled Dean&Francis multifunctional neural probes for precise integration of optogenetics and electrophysiology. Nature Communications, 2021, 12: 5871.
[27] Wentz CT, Bernstein JG, Monahan P, et al. A wirelessly powered and controlled device for optical neural control of freely-behaving animals. Journal of Neural Engineering, 2011, 8(4): 046021.
[28] Ausra J, Wu M, Zhang X, et al. Wireless, battery-free, subdermally implantable platforms for transcranial and longrange optogenetics in freely moving animals. Proceedings of the National Academy of Sciences, 2021, 118(30): e2025775118.
[29] Ouyang W, Lu W, Zhang Y, et al. A wireless and battery-less implant for multimodal closed-loop neuromodulation in small animals. Nature Biomedical Engineering, 2023, 7: 1252–1269.
[30] Chowdhury S, Yamanaka A. Fiberless optogenetics: recent advances and applications. In: Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond, 2021: 407-416.
[31] Wang Zhimin, Hu Ming, Xing Bengang. Application of near-infrared up-conversion nanoconverter in optogenetic regulation. Chinese Journal of Inorganic Chemistry, 2019, 36(06): 969-982.
[32] Ding H, Lv G, Shi Z, et al. Microscale optoelectronic infrared-to-visible upconversion device as the implantable light sources for optogenetics neuromodulation. In: Proceedings of Neurophotonics, SPIE, 2020, 11360: 79-84.
[33] Wang Y, Xie K, Yue H, et al. Flexible and fully implantable upconversion device for wireless optogenetic stimulation of the spinal cord in behaving animals. Nanoscale, 2020, 12(4): 2406- 2414.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.
This work is licensed under a Creative Commons Attribution 4.0 International License.
