Potential food factors affect the fatality rate of COVID-19: an analysis using multiple linear regression
DOI:
https://doi.org/10.61173/53019a85Keywords:
healthy diets, regression model, stepwise regressionAbstract
The COVID-19 pandemic has caused great harm to people around the world. This article explores the relationship between healthy diets and the fatality rate of COVID-19 from the perspective of healthy diets. This article collects data from Kaggle, pre-processes and standardizes it, conducts principal component analysis(PCA), divides it into five different dietary patterns(The contribution rate of these five dietary patterns is 72.917%, which can be interpreted as the principal component), and then constructs a multiple linear regression model. In the construction of this model, this article uses the idea of stepwise regression to remove variables that are not significant, leaving the parameters of the first and second principal components significantly non-zero. The results show that the estimated value of the parameter for the first dietary pattern in linear regression is 0.013, whereas the estimated value of the parameter for the second dietary pattern in linear regression is -0.005. Vegetable oils and vegetable products are negatively correlated with the fatality rate of COVID-19, while starchy root foods and animal products are positively correlated with it. Finally, the conclusion is drawn: In normal meals, it is more important to pay attention to the intake of vegetable foods, and try to ensure that the intake of meat foods should also be accompanied by a large amount of different types of vegetables. In the process of cooking, try to use vegetable oils such as soybean oil, olive oil, etc., which contain a lot of vitamin E and unsaturated fatty acids. For starchy root foods and certain high-protein, high-fat animal products, try to eat less in life. On the premise of ensuring good eating habits, it will have a good protective effect on COVID-19.
References
[1] Dhama, K., et al., Coronavirus Disease 2019-COVID-19. Clin Microbiol Rev, 2020. 33(4).
[2] Sharun, K., R. Tiwari, and K. Dhama, COVID-19 and sunlight: Impact on SARS-CoV-2 transmissibility, morbidity, and mortality. Ann Med Surg (Lond), 2021. 66: p. 102419.
[3] Alamri, F.F., et al., Association of Healthy Diet with Recovery Time from COVID-19: Results from a Nationwide Cross- Sectional Study. Int J Environ Res Public Health, 2021. 18(16).
[4] Kromhout, D., et al., The 2015 Dutch food-based dietary guidelines. Eur J Clin Nutr, 2016. 70(8): p. 869-78.
[5] Wang, H., et al., The role of high cholesterol in SARS-CoV-2 infectivity. J Biol Chem, 2023. 299(6): p. 104763. Dean&Francis
[6] van der Gaag, E., et al., Influence of Dietary Advice Including Green Vegetables, Beef, and Whole Dairy Products on Recurrent Upper Respiratory Tract Infections in Children: A Randomized Controlled Trial. Nutrients, 2020. 12(1).
[7] Galanakis, C.M., The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis. Foods, 2020. 9(4).
[8] Ostfeld, R.J., Definition of a plant-based diet and overview of this special issue. J Geriatr Cardiol, 2017. 14(5): p. 315.
[9] Campbell, J.L., COVID-19: Reducing the risk via diet and lifestyle. J Integr Med, 2023. 21(1): p. 1-16.
[10] Kim, H., et al., Plant-based diets, pescatarian diets and COVID-19 severity: a population-based case-control study in six countries. BMJ Nutr Prev Health, 2021. 4(1): p. 257-266.
[11] Cobre, A.F., et al., Influence of foods and nutrients on COVID-19 recovery: A multivariate analysis of data from 170 countries using a generalized linear model. Clin Nutr, 2022. 41(12): p. 3077-3084.
[12] Jayawardena, R., et al., Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes Metab Syndr, 2020. 14(4): p. 367-382.
[13] Polonikov, A., Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients. ACS Infect Dis, 2020. 6(7): p. 1558-1562.
[14] Maras, J.E., et al., Intake of alpha-tocopherol is limited among US adults. J Am Diet Assoc, 2004. 104(4): p. 567-75.
[15] Skrajnowska, D., et al., Covid 19: Diet Composition and Health. Nutrients, 2021. 13(9).
[16] Zhang, J.J., et al., Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality. Clin Rev Allergy Immunol,
[2023] 64(1): p. 90-107.
[17] Bouillon, R., et al., Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions. Endocr Rev, 2019. 40(4): p. 1109-1151.
[18] Chang, T.S., et al., Prior diagnoses and medications as risk factors for COVID-19 in a Los Angeles Health System. medRxiv, 2020.
[19] Panagiotou, G., et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity. Clin Endocrinol (Oxf),
[2020] 93(4): p. 508-511.
[20] Hernández, J.L., et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. J Clin Endocrinol Metab,
[2021] 106(3): p. e1343-e1353.
[21] Singh, A.K. and K. Khunti, COVID-19 and Diabetes. Annu Rev Med, 2022. 73: p. 129-147.
[22] Heydemann, A., An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus. J Diabetes Res, 2016. 2016: p. 2902351.
[23] Islam, M.S. and T. Loots du, Experimental rodent models of type 2 diabetes: a review. Methods Find Exp Clin Pharmacol,
[2009] 31(4): p. 249-61.
[24] Peltonen, L. and V.A. McKusick, Genomics and medicine. Dissecting human disease in the postgenomic era. Science,
[2001] 291(5507): p. 1224-9. Table 1: Explanatory data analysis of the variables studied(There is no standardization) Number Minimum Maximum Average Variance AlcoholicBeverages 162 0 15.37 3.0397 5.708 Animalfats 162 0.0018 1.3559 0.221723 0.078 AnimalProducts 162 1.7391 26.8865 12.171808 35.13 CerealsExcludingBeer 162 3.4014 29.8045 11.819564 34.738 Eggs 162 0.0239 1.696 0.466422 0.113 FishSeafood 162 0.0342 8.7959 1.33766 1.434 FruitsExcludingWine 162 0.6596 19.3028 5.657533 10.372 Meat 162 0.356 8.17 3.316145 3.027 MilkExcludingButter 162 0.0963 20.8378 6.618765 25.603 StarchyRoots 162 0.6796 27.7128 5.404408 32.309 SugarSweeteners 162 0.3666 9.7259 2.797319 2.398 Treenuts 162 0 0.8 0.118 0.022 VegetableOils 162 0.0915 2.2026 0.852935 0.203 Vegetables 162 0.857 19.2995 6.047441 12.845 VegetalProducts 162 23.1132 48.2585 37.824711 35.134 Dean&Francis Table 2: Five principal components and the parameters corresponding to each variable Principal component coefficient 1 2 3 4 5 AlcoholicBeverages 0.21 -0.26 0.32 -0.16 0.24 Animalfats 0.32 -0.23 -0.01 -0.06 0.17 AnimalProducts 0.44 -0.06 -0.07 -0.00 -0.01 CerealsExcludingBeer -0.26 0.22 -0.20 -0.50 0.07 Eggs 0.27 0.34 0.04 0.05 0.11 FishSeafood 0.00 0.32 0.32 0.18 0.50 FruitsExcludingWine -0.08 0.10 0.26 0.57 -0.46 Meat 0.30 0.20 0.30 0.06 -0.00 MilkExcludingButter 0.37 -0.23 -0.27 -0.06 -0.14 StarchyRoots -0.26 -0.39 0.20 0.13 0.23 SugarSweeteners 0.18 0.32 0.30 -0.19 -0.29 Treenuts 0.05 0.22 -0.29 0.33 0.52 VegetableOils -0.01 0.39 0.03 -0.34 -0.03 Vegetables 0.05 0.21 -0.54 0.29 -0.09 VegetalProducts -0.44 0.06 0.07 0.00 0.01 AlcoholicBeverages 0.21 -0.26 0.32 -0.16 0.24 Table 3: Stepwise regression coefficient standard deviation T-value P-value Intercept 0,038922 0.003053 12.748 <2e-16 Factor1 0.012983 0.001385 9.374 <2e-16 Factor2 -0.005307 0.002205 -2.407 0.0173 Factor3 -0.003520 0.002405 -1.464 0.1452 Figure 1:Heatmap for the 15 variances Figure 2: The fitted image of stepwise regression(regard factor1 as independent variance) Dean&Francis Figure 3: The fitted image of stepwise regression(regard factor2 as independent variance)
Downloads
Published
Issue
Section
License
Copyright (c) 2024 by the authors.

This work is licensed under a Creative Commons Attribution 4.0 International License.
