GSK3: The Shared Target of Circadian Rhythm and Lithium Treatment in Bipolar Disorder
DOI:
https://doi.org/10.61173/b1xvkf28Keywords:
Bipolar Disorder, Circadian Rhythm, Lithium, GSK-3Abstract
Bipolar disorder is a severe emotional disorder that causes significant damage to patients’ cognitive functions. Although the clinical manifestations of bipolar disorder are clear, its pathophysiological mechanisms are currently not well understood. The theme of this review is to explore the pathophysiological mechanisms of bipolar disorder. Starting from the lithium treatment mechanism, the author identified an important target - GSK-3, by reviewing previous literature. Research has shown that GSK-3 plays a crucial role in the bipolar disorder. This review provides an introduction to GSK-3 and its probable mechanisms that contribute to bipolar disease. It also examines the role of GSK-3 in bipolar disorder from both the standpoint of how it develops and how it might be treated. By studying GSK-3, we can augment our comprehension of bipolar disorder and further delve into our grasp of this condition.
References
[1] SHEN Qi, TAN Xing, WANG Weizhong. Research progress of autonomic imbalance caused by circadian rhythm disorder[J]. Journal of Naval Military Medical University, 2024, 45(03):328- 332.
[2] CHENG Man,YU Shuang,LI Juan,et al. Role of the supraoptic nucleus in circadian rhythms[J]. Life Science,2015,27(11):1380-1385.
[3] NIE Oriqing, JIANG Hong. Progress of research on the role and mechanism of circadian rhythm disruption in acute myocardial infarction. Advances in Cardiovascular Disease,2023,44(12):1103-1106.
[4] WU Juan, WANG Bang, CHEN Shoushuo, et al. MRI diagnosis of gliomas and characterization of circadian rhythm gene CRY1 expression in gliomas. Chinese Journal of CT and MRI, 2023, 21(12):31-34.
[5] TIAN Si-wen, LIU Qiuping, MA Ji-xian, et al. Progress in the study of the correlation between circadian rhythms and biological clock genes and the development of diabetic retinopathy. International Journal of Ophthalmology, 2023, 23(08):1290-1294.
[6] Tian SX. Bipolar disorder: a roller coaster of emotions[N]. Medicine and health care newspaper,2024-02-07(011).
[7] YU Hao, WU Yao, ZOU Shaohong. Progress of genetic studies on cognitive impairment and brain-derived neurotrophic factor in bipolar disorder. Neurological Diseases and Mental Health,2023,23(12):895-900.
[8] Bao Shuang,Ren Yan,Cui Xiaohong,et al. Progress in the study of biological markers of bipolar disorder. Medical Revi ew,2019,25(20):3991-3995+4001.
[9] Liu Tiebang. Clinical practice of pharmacotherapy for bipolar disorder[J]. Sichuan Mental Health,2023,36(06):481-484.
[10] LU T, JIANG Z, LAN WEIYA, et al. Progress of GSK-3- mediated signaling pathway in rheumatoid arthritis. Chongqing Med,2024,53(03):451-455.
[11] ZHU Jianglan, SHI Bei. Mechanism of cytoprotective effects of glycogen synthase kinase 3 signaling pathway. Medical Review,2014,20(11):1945-1947.
[12] Xuemei La, Yuan Guo, Jian Liu, et al. 5-HT transmitter system regulates psychiatric symptoms and cognitive impairment in Parkinson’s disease[J]. Advances in Physiological Sciences,2023,54(03):177-184.
[13] Chen L, Salinas GD, Li X. Regulation of serotonin 1B receptor by glycogen synthase kinase-3. Mol Pharmacol, 2009, 76(6):1150-1161.
[14] QIN Yuncong, XIAO Le. Research progress of bipolar disorder and sleep disorders. World Journal of Sleep Medicine,2023,10(07):1725-1728.
[15] Grillo CA, Piroli GG, Kaigler KF, Wilson SP, Wilson MA, Reagan LP. Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats. Behav Brain Res, 2011, 222(1):230-235.
[16] Liu J, Zhou B, Yan M, Huang R, Wang Y, He Z, Yang Y, Dai C, Wang Y, Zhang F, Zhai Q. CLOCK and BMAL1 Regulate Muscle Insulin Sensitivity via SIRT1 in Male Mice. Endocrinology, 2016, 157(6):2259-2269.
[17] Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature, 1995, 378(6559):785-789.
[18] GUO Bao, LIU Ziming, JING Yongshuai, et al. Correlation Dean&Francis and targeting of Wnt signaling pathway with Alzheimer’s disease[J]. Journal of Neuropharmacology,2023,13(01):56-64.
[19] QIN Weizhuo, FEI Gaoqiang, ZHANG Xuening, et al. Progress of Wnt/β- catenin signaling pathway in diseases[J]. Modern Medicine,2023,51(09):1337-1345.
[20] Kaakour D, Fortin B, Masri S, Rezazadeh A. Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview. Clin Med Insights Oncol, 2023, 17:11795549231211521.
[21] Wei YM. Behavioral changes in chronic cocaine rats and its relationship with glycogen synthase kinase 3β in the brain[D]. Fujian Medical University,2010.
[22] Iitaka C, Miyazaki K, Akaike T, Ishida N. A role for glycogen synthase kinase-3beta in the mammalian circadian clock. J Biol Chem, 2005, 280(33):29397-29402.
[23] Moreira J, Geoffroy PA. Lithium and bipolar disorder: Impacts from molecular to behavioural circadian rhythms. Chronobiol Int, 2016, 33(4):351-373.
[24] WU Donghui,LIU Tiebang. Intracellular signaling pathways and bipolar disorder[J]. International Journal of Psychiatry,2008(02):119-122.
[25] Keshavarz M, Emamghoreishi M, Nekooeian AA, J Warsh J, Zare HR. Increased bcl-2 Protein Levels in Rat Primary Astrocyte Culture Following Chronic Lithium Treatment. Iran J Med Sci, 2013, 38(3):255-262.
[26] Snitow ME, Bhansali RS, Klein PS. Lithium and Therapeutic Targeting of GSK-3. Cells, 2021 Jan 28, 10(2):255.
[27] Cui Y, Xue R, Zhang YZ, et al. Progress of research on the role of glycogen synthase kinase-3β in the pathogenesis and treatment of bipolar affective disorder. Chinese Journal of Pharmacology and Toxicology,2016,30(04):362-368.
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